病毒学
生物
牛痘
抗原
重组DNA
免疫系统
病毒
宫颈癌
免疫学
子宫颈
CD8型
癌症
基因
遗传学
作者
Zhonghu He,Anthony P Wlazlo,Dariusz W. Kowalczyk,Jun Cheng,Zhiquan Xiang,Wynetta Giles-Davis,Hildegund C. J. Ertl
出处
期刊:Virology
[Elsevier]
日期:2000-04-01
卷期号:270 (1): 146-161
被引量:104
标识
DOI:10.1006/viro.2000.0271
摘要
Most cancerous lesions of the uterine cervix are linked to persistent infections with human papillomaviruses (HPV), most notably HPV-16 or -18. Vaccine-induced immune responses to the HPV early antigens E6 and E7, which contribute to cell transformation and are thus expressed in these cervical cancers, could potentially eradicate malignant cells. We generated recombinant vaccines based on E1-deleted adenovirus human strain 5 or on vaccinia virus strain Copenhagen expressing either the E6 or E7 oncoproteins of HPV-16. The different vaccines were compared in two experimental mouse tumor models employing Balb/c or C57Bl/6 mice. Data presented here demonstrate that depending on the model either CD4(+) or CD8(+) T cells provide protection to tumor cell challenge, resulting in striking differences in the efficacy of the four vaccines under investigation.
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