氧化应激
转录因子
NF-κB
信号转导
活性氧
细胞生物学
机制(生物学)
NFKB1型
免疫系统
促炎细胞因子
炎症
化学
生物
免疫学
基因
生物化学
认识论
哲学
作者
Nanxin Li,Michael Karin
出处
期刊:PubMed
日期:1999-07-01
卷期号:13 (10): 1137-43
被引量:249
摘要
NF-kappaB is a dimeric transcription factor that is involved in the regulation of a large number of genes that control various aspects of the immune and inflammatory response. It is activated by a variety of stimuli ranging from cytokines, to various forms of radiation, to oxidative stress (such as exposure to H2O2). Recent studies have advanced our understanding of the signal transduction pathway leading to NF-kappaB activation by cytokines and will provide insights for the mechanism by which NF-kappaB is regulated by oxidative stress. An important question that is yet to be answered is whether reactive oxygen species play a physiological role in NF-kappaB activation.
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