免疫学
免疫系统
生物
小胶质细胞
中枢神经系统
归巢(生物学)
多发性硬化
神经炎症
髓鞘
炎症
先天免疫系统
先天性淋巴细胞
神经科学
生态学
作者
Junwei Hao,Ruolan Liu,Wenhua Piao,Qinghua Zhou,Timothy Vollmer,Denise I. Campagnolo,Rong Xiang,Antonio La Cava,Luc Van Kaer,Fu‐Dong Shi
摘要
Natural killer (NK) cells of the innate immune system can profoundly impact the development of adaptive immune responses. Inflammatory and autoimmune responses in anatomical locations such as the central nervous system (CNS) differ substantially from those found in peripheral organs. We show in a mouse model of multiple sclerosis that NK cell enrichment results in disease amelioration, whereas selective blockade of NK cell homing to the CNS results in disease exacerbation. Importantly, the effects of NK cells on CNS pathology were dependent on the activity of CNS-resident, but not peripheral, NK cells. This activity of CNS-resident NK cells involved interactions with microglia and suppression of myelin-reactive Th17 cells. Our studies suggest an organ-specific activity of NK cells on the magnitude of CNS inflammation, providing potential new targets for therapeutic intervention.
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