Porphyrin-Based Covalent Organic Framework Hydrogel Integrated with Hyaluronic Acid for Photothermal Antibacterial Wound Healing

Covalent organic frameworks (COFs) with tailorable functional architectures hold promise in biomedical fields, while the conventional powdery morphology restricts practical use. In this study, a porphyrin-based COF with abundant amino groups has been synthesized through a defect engineering strategy, which further reacts with hyaluronic acid (HA) through an amide condensation reaction to obtain a COF-HA hydrogel. The hybrid hydrogel retains the photochemical properties of porphyrin-based COFs and is also endowed with the advantages of hydrogels, including good adhesion, plasticity, and biocompatibility. The hybrid material exhibits excellent photothermal conversion performance, achieving a temperature elevation of 29 °C under 808 nm laser irradiation (2 W/cm2) within 5 min. Additionally, the composite achieves complete antibacterial efficacy against Staphylococcus aureus and Escherichia coli under 10 min of the NIR irradiation. Furthermore, as a wound dressing, the composite hydrogel can effectively alleviate inflammatory response in S. aureus-infected cutaneous wounds, thereby contributing to prominent acceleration of wound healing and skin regeneration. This work broadens the translational prospects of porphyrin-functionalized COFs for antibacterial treatment and wound repair applications.