A 24 year old female patient from Bedelle, Oromia region, Ethiopia presented with progressive and recurrent quadriparesis of a five year duration and was diagnosed to have acute myelitis and neuritis, Neuromyelitis optica (NMO). To our knowledge NMO has never been reported from Ethiopia. Hence, we discuss the case presentation in light of the available literature on the topic. Key words: Neuro Myelitis Optica, Ethiopia