间充质干细胞
细胞生物学
毛乳头
毛囊
细胞生长
维斯坎
MAPK/ERK通路
生长因子
化学
体内
干细胞
生物
信号转导
细胞外基质
受体
生物化学
生物技术
蛋白多糖
作者
Ramya Lakshmi Rajendran,Prakash Gangadaran,Soon Sun Bak,Ji Min Oh,S Kalimuthu,Ho Won Lee,Se Hwan Baek,Zhu Li,Young Kwan Sung,Shin Young Jeong,Sang‐Woo Lee,Jaetae Lee,Byeong‐Cheol Ahn
标识
DOI:10.1038/s41598-017-15505-3
摘要
Abstract Hair loss is a common medical problem. In this study, we investigated the proliferation, migration, and growth factor expression of human dermal papilla (DP) cells in the presence or absence of treatment with mesenchymal stem cell extracellular vesicles (MSC-EVs). In addition, we tested the efficacy of MSC-EV treatment on hair growth in an animal model. MSC-EV treatment increased DP cell proliferation and migration, and elevated the levels of Bcl-2, phosphorylated Akt and ERK. In addition; DP cells treated with MSC-EVs displayed increased expression and secretion of VEGF and IGF-1. Intradermal injection of MSC-EVs into C57BL/6 mice promoted the conversion from telogen to anagen and increased expression of wnt3a, wnt5a and versican was demonstrated. The first time our results suggest that MSC-EVs have a potential to activate DP cells, prolonged survival, induce growth factor activation in vitro , and promotes hair growth in vivo .
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