亲核细胞
烷基化
化学
苯
氢化物
镁
钙
锂(药物)
有机化学
金属
催化作用
生物
内分泌学
作者
Andrew S. S. Wilson,Michael S. Hill,Mary F. Mahon,Chiara Dinoi,Laurent Maron
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2017-12-01
卷期号:358 (6367): 1168-1171
被引量:180
标识
DOI:10.1126/science.aao5923
摘要
Calcium can breach benzene's defenses Calcium plays a major, multifaceted role in biology and mineralogy. In organic chemistry, though, it is largely overlooked and overshadowed by the carbon compounds of its cousins lithium and magnesium. Wilson et al. now report that the element was just biding its time: Several organocalcium compounds that they prepared can alkylate benzene by displacing a hydride, with no need for a more conventionally reactive leaving group such as chloride (see the Perspective by Mulvey). This surprising, previously elusive reaction attests to the unusual nucleophilicity of the carbons bound to calcium. Science , this issue p. 1168 ; see also p. 1132
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