TRF2 Recruits RTEL1 to Telomeres in S Phase to Promote T-Loop Unwinding

(Molecular Cell 57, 622–635; February 19, 2015) It has come to our attention that in the above article, the Figures 3G and 6I as well as the legends for these figures had indicated the lagging and leading strands incorrectly. The green label should be marked as the lagging strand and the red label should be marked as the leading strand. In addition, the second sentence in the last paragraph of the results was inadvertently written as “Inactivation of TRF2 in TRF2F/− MEFs complemented with Myc-TRF2I124D resulted in a greater than 5-fold induction in the frequency of T-SCEs with preferential addition of lagging telomere DNA when compared with cells expressing WT Myc-TRF2 (Figure 6I)” and should read “Inactivation of TRF2 in TRF2F/− MEFs complemented with Myc-TRF2I124D resulted in a greater than 5-fold induction in the frequency of T-SCEs with preferential addition of leading telomere DNA when compared with cells expressing WT Myc-TRF2 (Figure 6I).” This correction does not affect the description of the results in the article or the conclusions of our study. The authors regret this error, which has been corrected in the online version.Figure 3GAlterations of RTEL1 in the C4C4 Domain Result in Telomeric Dysfunction (original)View Large Image Figure ViewerDownload Hi-res image Download (PPT)Figure 6IDisruption of the RTEL1 Binding Site in the TRFH Domain of TRF2 Leads to Abnormal Telomere Phenotypes (corrected)View Large Image Figure ViewerDownload Hi-res image Download (PPT)Figure 6IDisruption of the RTEL1 Binding Site in the TRFH Domain of TRF2 Leads to Abnormal Telomere Phenotypes (original)View Large Image Figure ViewerDownload Hi-res image Download (PPT) TRF2 Recruits RTEL1 to Telomeres in S Phase to Promote T-Loop UnwindingSarek et al.Molecular CellJanuary 22, 2015In BriefRTEL1 is an essential DNA helicase that disassembles telomere loops (t-loops) to maintain integrity of chromosome ends. Sarek et al. now establish the mechanism by which RTEL1 is recruited to telomeres to execute t-loop unwinding, which is dependent on an S phase-specific interaction between RTEL1 and the shelterin component TRF2. Full-Text PDF Open Access