tert-Butyl Hydroperoxide-Mediated Synthesis of Phosphoroselenoates

Phosphoroselenoates have found widespread applications in the fields of organic synthesis and drug discovery.To this end, continuous efforts have been devoted to the development of novel and efficient methods for the synthesis of these compounds.A new method for the synthesis of phosphoroselenoates through oxidative coupling reaction of diselenides with phosphites by the utilization of t-butyl hydroperoxide (TBHP) as oxidant was herein developed.The distinct advantages of this protocol over all previous methods include mild reaction conditions, broad substrate scope, excellent yields, as well as transition metal-and base-free.