A Preliminary view on some Genetic Aspects of Irritable Bowel Syndrome with regards to Neuropsychiatric Manifestations –

Since the newest functional gastrointestinal disorders diagnostic criteria (ROME IV), the formely functional bowel disorder – irritable bowel syndrome (IBS) – is currently known as a common chronic disorder of the brain – gut interaction. The main clinical symptomatology including abdominal pain, discomfort, and altered gastrointestinal motility, as well as the absence of any organic impairment or significant histological changes led to the confirmed hypothesis of multicomponent pathology and multifactorial etiogenesis. Thus, considering our previous experience in this area of research, this mini-review aimed to present a preliminary view of the possible genetic component underlying or predisposing to neurolopsychiatric and gastrointestinal impairments co-ocurring in IBS.