环状RNA
生物发生
计算生物学
核糖核酸
RNA剪接
外显子
生物
癌症
小RNA
遗传学
基因
作者
Yue Zhang,Xinyi Zhang,Yumeng Xu,Shikun Fang,Ying Ji,Ling Lü,Wenrong Xu,Hui Qian,Liang Zhao
标识
DOI:10.3389/fonc.2022.845703
摘要
Circular RNAs (circRNAs) are non-coding single-stranded covalently closed circular RNA, mainly produced by reverse splicing of exons of precursor mRNAs (pre-mRNAs). The characteristics of high abundance, strong specificity, and good stability of circRNAs have been discovered. A large number of studies have reported its various functions and mechanisms in biological events, such as the occurrence and development of cancer. In this review, we focus on the classification, characterization, biogenesis, functions of circRNAs, and the latest advances in cancer research. The development of circRNAs as biomarkers in cancer diagnosis and treatment also provides new ideas for studying circRNAs research.
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