Solvation Effects on Quantum Tunneling Reactions

Conspectus A decisive factor for obtaining high yields and selectivities in organic synthesis is the choice of the proper solvent. Solvent selection is often guided by the intuitive understanding of transition state–solvent interactions. However, quantum-mechanical tunneling can significantly contribute to chemical reactions, circumventing the transition state and thus depriving chemists of their intuitive handle on the reaction kinetics. In this Account, we aim to provide rationales for the effects of solvation on tunneling reactions derived from experiments performed in cryogenic matrices. The tunneling reactions analyzed here cover a broad range of prototypical organic transformations that are subject to strong solvation effects. Examples are the hydrogen tunneling probability for the cis – trans isomerization of formic acid which is strongly reduced upon formation of hydrogen-bonded complexes and the [1,2]H-shift in methylhydroxycarbene where a change in product selectivity is predicted upon interaction with hydrogen bond acceptors. Not only hydrogen but also heavy atom tunneling can exhibit strong solvent effects. The direction of the nearly degenerate valence tautomerization between benzene oxide and oxepin was found to reverse upon formation of a halogen or hydrogen bond with ICF 3 or H 2 O. But even in the absence of strong noncovalent interactions such as hydrogen or halogen bonding, solvation can have a decisive effect on tunneling as evidenced by the Cope rearrangement of semibullvalenes via heavy-atom tunneling. Can quantum tunneling be catalyzed? The acceleration of the ring expansion of 1 H -bicyclo[3.1.0.]-hexa-3,5-dien-2-one by complexation with Lewis acids provides a proof-of-concept for tunneling catalysis. Two concepts are central for the explanation and prediction of solvation effects on tunneling phenomena: a simple approach expands the Born–Oppenheimer approximation by separating nuclear degrees of freedom into intra- and intermolecular degrees. Intermolecular movements represent the slowest motions within molecular aggregates, thus effectively freezing the position of the solvent in relation to the reactant during the tunneling process. Another useful approach is to treat reactants and products by separate single-well potentials, where the intersection represents the transition state. Thus, stabilization of the reactants via solvation should result in an increase in barrier heights and widths which in turn lowers tunneling probabilities. These simple models can predict trends in tunneling kinetics and provide a rational basis for controlling tunneling reactions via solvation.