内囊
医学
改良兰金量表
丘脑
脑出血
逻辑回归
优势比
内科学
物理疗法
磁共振成像
白质
缺血
放射科
缺血性中风
蛛网膜下腔出血
作者
Candice Delcourt,Shigeo Sato,Shihong Zhang,Else Charlotte Sandset,Danni Zheng,Xiaoying Chen,Maree L. Hackett,Hisatomi Arima,Jun Hata,Emma Heeley,Rustam Al‐Shahi Salman,Thompson G. Robinson,Leo Davies,Pablo M. Lavados,Richard Lindley,Christian Stapf,John Chalmers,Craig S. Anderson
出处
期刊:Neurology
[Ovid Technologies (Wolters Kluwer)]
日期:2017-04-11
卷期号:88 (15): 1408-1414
被引量:98
标识
DOI:10.1212/wnl.0000000000003771
摘要
To clarify associations between intracerebral hemorrhage (ICH) location and clinical outcomes among participants of the main phase Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial (INTERACT2).Associations between ICH sites and poor outcomes (death [6] or major disability [3-5] of modified Rankin Scale) and European Quality of Life Scale (EQ-5D) utility scores at 90 days were assessed in logistic regression models.Of 2,066 patients included in the analyses, associations were identified between ICH sites and poor outcomes: involvement of posterior limb of internal capsule increased risks of death or major disability (odds ratio [OR] 2.10) and disability (OR 1.81); thalamic involvement increased risks of death or major disability (OR 2.24) and death (OR 1.97). Involvement of the posterior limb of the internal capsule, thalamus, and infratentorial sites were each associated with poor EQ-5D utility score (≤0.7 [median]; OR 1.87, 2.14, and 2.81, respectively). Posterior limb of internal capsule involvement was strongly associated with low scores across all health-related quality of life domains. ICH encompassing the thalamus and posterior limb of internal capsule were associated with death or major disability, major disability, and poor EQ-5D utility score (OR 1.72, 2.26, and 1.71, respectively).Poor clinical outcomes are related to ICH affecting the posterior limb of internal capsule, thalamus, and infratentorial sites. The highest association with death or major disability and poor EQ-5D utility score was seen in ICH encompassing the thalamus and posterior limb of internal capsule.NCT00716079.
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