[Influence of drug compatibility on extractive retes of chlorogenic acid and isochlorogenic acid in simiaoyonglan tang decoction].

OBJECTIVE: To study the influence of drug compatibility on the extractive rates of chlorogenic acid and isochlorogenic acid in Simiaoyonglan Tang (SMYAT) decoction. METHOD: The contents of chlorogenic acid and isochlorogenic acid in SMYAT decoction, Flos Lonicerae and Flos Lonicerae in combination with other single drugs were determined by TLC-UV spectrophotometry respectively. The data from this experiment were treated statistically. RESULTS: The contents of chlorogenic acid in other five prescriptions of different compatibilities decreased markedly in comparison with those in Flos Loniceraés decoction (P < 0.01). The content of isochlorogenic acid in SMYAT decoction as a whole was about the same as thar in Flos Loniceraés decoction, but decreased significantly in other prescriptions of different compatibilities (P < 0.01). CONCLUSION: Drug compatibility is one of the main causes for changes of chlorogenic acid and isochlorogenic acid contents in SMYAT decoction.