Mitochondrial VDAC and Its Complexes

This chapter contains sections titled: Abstract The Role of VDAC in Controlling the Interaction of Mitochondria with the Cytosol Molecular Structure and Membrane Topology of VDAC VDAC Conductance, Voltage Dependence, and Ion Selectivity The Physiological Significance of VDAC Voltage Gating VDAC Isoforms and Functions Mitochondria and Apoptosis VDAC and ANT May Form the Mitochondrial Permeability Transition Pore Accessory MPT Pore Subunits ANT Knockout Studies The Role of VDAC in Organizing Kinases at the Mitochondrial Surface Hexokinase–VDAC–ANT Complexes in Tumor Cells Hexokinase as a Marker Enzyme of Contact Sites VDAC–ANT Complexes VDAC–ANT Complexes Contain Cytochrome c VDAC Oligomerization and Cytochrome c Binding Possible Function of Cytochrome c in the Contact Sites Cholesterol and Cardiolipin Influence VDAC Structure and Function The Importance of VDAC Complexes in Regulation of Energy Metabolism and Apoptosis Suppression of Bax-dependent Cytochrome c Release and Permeability Transition by Hexokinase Suppression of Permeability Transition and Cytochrome c Release by Mitochondrial Creatine Kinase The General Importance of the Creatine Kinase System in Heart Performance The Central Regulatory Role of ANT References