Surgical endodontics becomes necessary when conventional therapy is not feasible or successful. The most frequently performed procedures; in this situation is apicoectomy and retrograde filling in the resected root end. The purpose of this study was to compare between the sealing abilities as well as the working time of three root end filling materials; self-adhesive cement (Rely X Unicem ) and composite resin (Tetric Ceram composite resin) combined with two different types of two-step bonding agents, etch-and-rinse (Excite- Ivoclar- Vivadent)versus self-etch (Clearfil SE-Bond-Kuraray) systems. Methodology: thirty recently extracted human, permanent single-canalled teeth were selected for this study. Endodontic access cavity preparation was done in all teeth, and finally coronal access was sealed with composite .Teeth were randomly assigned into two equal groups :Group A(no bevel) : 3 mm of the roots were resected in a plane perpendicular to the long axis of the tooth with no bevel , and then Class I root-end cavities were prepared using fissure bur to the depth of 3 mm parallel to the long axis of the root .Group B (45 0 bevel ): 3 mm of the roots were apically resected using high-speed carbide bur at 45 o beveled plane labio -lingually and then Class I root-end cavities were prepared .Each group was further subdivided into 3 subgroups of 5 teeth each according to the material used. Teeth were immersed in2% methylene blue dye for a period of twenty four hours, after which they were retrieved, washed, sectioned and the apical dye penetration were measured. Also the working time was measured for each material. Results: the results showed that RelyX groups had the best sealing abilities and the minimum working time, followed by Clearfil SE-Bond and Excite groups. (Mohamed Sherif Mohamed Salah El Din Hassan Farag and Nagwa Mohamed Aly Khattab Evaluation of Three Resin-Based Root End Filling Materials in Surgical Endodontics. Journal of American Science 2011; 7(12): 268-274).(ISSN: 1545-1003). http://www.americanscience.org. Keyword: Pediatric surgery, Resin-based materials, Root end filling materials, Surgical endodontics.