纳曲酮
渴求
安慰剂
苦恼
焦虑
精神科
心理学
酒精依赖
麻醉剂拮抗剂
人口
医学
临床心理学
内科学
酒
类阿片
上瘾
病理
受体
化学
替代医学
环境卫生
生物化学
作者
Joseph R. Volpicelli,Karen L. Clay,Nathan T. Watson,Charles P. O’Brien
出处
期刊:PubMed
日期:1995-01-01
卷期号:56 Suppl 7: 39-44
被引量:52
摘要
The pooled results of 99 subjects from our Veterans Affairs population show that naltrexone-treated subjects had a greater reduction in alcohol craving, number of drinking days, and alcoholic relapse rates when compared with placebo-treated subjects. Based on our findings and results from other double-blind trials of naltrexone, we conclude that naltrexone is a safe and useful adjunct in the rehabilitation of alcohol-dependent patients. Increased baseline levels of psychological distress and craving as well as higher levels of somatic distress, anxiety, phobic anxiety, and obsessive-compulsive symptoms predicted an increased number of drinking days during the study. Significant interactions between naltrexone treatment, initial craving, and somatic distress suggest that naltrexone may be useful for subjects who present with high levels of craving and somatic symptoms.
科研通智能强力驱动
Strongly Powered by AbleSci AI