厌食
赤眼蜂
呕吐毒素
生物
生物测定
食物摄入量
内科学
内分泌学
厌食症
免疫系统
体重
生理学
真菌毒素
动物科学
医学
免疫学
食品科学
玉米赤霉烯酮
生态学
作者
Erica Clark,Brenna M. Flannery,James J. Pestka
出处
期刊:Toxins
[Multidisciplinary Digital Publishing Institute]
日期:2015-07-29
卷期号:7 (8): 2845-2859
被引量:23
标识
DOI:10.3390/toxins7082845
摘要
Deoxynivalenol (DON, vomitoxin), a common trichothecene mycotoxin found in cereal foods, dysregulates immune function and maintenance of energy balance. The purpose of this study was to determine if sex differences are similarly evident in DON’s anorectic responses in mice. A bioassay for feed refusal, previously developed by our lab, was used to compare acute i.p. exposures of 1 and 5 mg/kg bw DON in C57BL6 mice. Greater anorectic responses were seen in male than female mice. Male mice had higher organ and plasma concentrations of DON upon acute exposure than their female counterparts. A significant increase in IL-6 plasma levels was also observed in males while cholecystokinin response was higher in females. When effects of sex on food intake and body weight changes were compared after subchronic dietary exposure to 1, 2.5, and 10 ppm DON, males were found again to be more sensitive. Demonstration of male predilection to DON-induced changes in food intake and weight gain might an important consideration in future risk assessment of DON and other trichothecenes.
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