Subretinal tissue plasminogen activator in polypoidal choroidal vasculopathy-related submacular haemorrhage and exudative retinal detachment

This report highlights the successful management of a large submacular haemorrhage associated with idiopathic polypoidal choroidal vasculopathy in a woman in her late 50s who presented with sudden vision loss in her left eye. Multilayered haemorrhages involving the macula were confirmed through funduscopy and swept-source optical coherence tomography. The patient underwent pars plana vitrectomy with subretinal recombinant tissue plasminogen activator injection, fluid-gas exchange with sulphur hexafluoride, and intravitreal ranibizumab, followed by prone positioning postoperatively. At 1 week, significant resolution of subretinal haemorrhage and improvement in exudative retinal detachment were observed. By 3 months, best-corrected visual acuity improved to 20/60, with consolidation of the haemorrhage and shrinkage of the pigment epithelial detachment.