Cu(II)/Photoredox-Catalyzed Aminoacylation of Vinyl Bromides

A novel C–C coupling reaction of vinyl bromides with carboxamides has been developed through Cu(OAc) 2 /photocatalysis. This process features regioselective carboxamido carbon-vinylation under mild reaction conditions. Mechanistic studies suggest that the formation of an acyl-Cu(I) intermediate plays a crucial role with regard to enabling this transformation.