Comorbidity in Venous Thromboembolic Disease

Venous thromboembolic disease (VTE) is the third most common vascular disease, immediately after ischemic heart disease and cerebrovascular disease. Its annual incidence is estimated at 1–2 cases 1000 h, but shows a progressive increase with increasing age. Population aging in European Union is one of the main factors related to the increase in VTE. Comorbidity is frequent in the adult population, and chronic diseases, such as chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis, heart failure, etc., have an impact on the prognosis and survival of the individual. Acute VTE is associated with frequent entities (cardiovascular, metabolic, respiratory, psychiatric, etc.). The study of comorbidity in patients with VTE can be performed through different procedures, such as the RIETE registry (Computerized Thromboembolic Disease Registry), an international, multicenter, observational registry, which includes patients with VTE from 2001 to 2024, with more than 100,000 patients included and which includes a registry of comorbidity data. The analysis of codified hospital discharge reports (configuration management database (CMBD)) of the National Health System (NHS) reflects the clinical, sociodemographic, and comorbidity characteristics. Other procedures by means of validated Scores or the Charlson index, and comorbidomes. Cancer and thrombocytosis were the comorbidities mostly related to mortality in VTE.