纳米凝胶
寡核苷酸
DNA
剪接
化学
生物物理学
纳米技术
材料科学
生物化学
生物
基因
药物输送
作者
Yuwei Hu,Feng Chen,Hongfang Lu,Susi Tan,Yujie Ke,Wei Wei Loh,Eugene Jia Hao Soh,Agarwal Taniya,Tommaso Tabaglio,Dave Keng Boon Wee,Jackie Y. Ying
摘要
A self-cleavable DNA nanogel loaded with splice-switch oligonucleotide (SSO) has been developed. Under acidic conditions (pH 5.0), cleavage of the acid-labile chemical linker and generation of the i-motif structure led to the disintegration of the DNA nanogel and efficient release of SSO in its unaltered native state.
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(2025-6-4)
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