细胞减少
造血
恶性肿瘤
体细胞
癌症的体细胞进化
癌症
生物
免疫学
肿瘤科
内科学
医学
骨髓
遗传学
干细胞
基因
作者
Kelly E. Craven,Mark D. Ewalt
标识
DOI:10.1016/j.cll.2023.06.001
摘要
Premalignant clonal hematopoiesis is the presence of somatic alterations in the blood of otherwise healthy individuals. Although the condition is not considered as a cancer, it carries an increased risk of developing a hematologic malignancy, particularly in those with large neoplastic clones, multiple pathogenic mutations, and high-risk mutations. In addition to the increased risk of malignancy, clonal hematopoiesis carries a markedly increased risk of cardiovascular events and death. Appropriate identification of this entity is critical to mitigate cardiovascular risk factors and ensure appropriate monitoring for the emergence of blood cancer.
科研通智能强力驱动
Strongly Powered by AbleSci AI