Mapping Brain Circuit Function to Symptoms and Behavioral Dimensions of Depression and Anxiety

A goal for our field is to identify subtypes of depression and anxiety that reflect coherent profiles of neural circuit function and are clinically meaningful for informing treatment decisions. We developed and validated a functional imaging system for quantifying subject-level circuit metrics, focusing on six circuits implicated in depression and anxiety. Working hypotheses were that specific types of circuit function map to specific clinical phenotypes and that distinct or partially overlapping circuit function predicts treatment response.