Cryptococcosis: update on therapeutics and new targets

While progress continues to be made in the therapy of cryptococcosis by finding better ways to use existing antifungal agents and improve clinical management it is possible that this strategy is reaching its asymptote. Consequently, transformative reductions in mortality and morbidity are likely to require new antifungal agents and/or adjunctive immunotherapies. Fortunately, there are there several promising approaches in the horizon that will hopefully future drive clinical investigation.