医学
银屑病
内科学
前瞻性队列研究
队列
逻辑回归
置信区间
队列研究
临床试验
皮肤病科
作者
Joy Q. Jin,Angel M. Cronin,Carla Roberts-Toler,Samuel Yeroushalmi,Edward Hadeler,Riley K. Spencer,Kareem G. Elhage,George Gondo,Elizabeth A. Wallace,Soumya Reddy,George Han,Jessica Kaffenberger,Mitchell S. Davis,Marwa Hakimi,Jose U. Scher,April W. Armstrong,Tina Bhutani,Robert R. McLean,Wilson Liao
标识
DOI:10.1016/j.jaad.2023.06.058
摘要
Psoriasis patients with poor therapeutic response to multiple biologic agents are not well-characterized.To describe the characteristics associated with development of multiple biologic failure (MBF) versus good clinical response (GR) to the first biologic.This prospective cohort analysis evaluated patients in the multicenter CorEvitas Psoriasis Registry who initiated their first biologic between 2015 and 2020 and were followed for ≥24 months. Multivariable logistic regression identified sociodemographic, clinical, and patient-reported outcomes that differed between MBF (discontinued ≥2 biologics of different classes, each used for ≥90 days, due to inadequate efficacy) and GR (continued use of first biologic for ≥2 years) patients.One thousand thirty-nine patients were analyzed (490 GR [47.2%], 65 MBF [6.3%]). Female sex, shorter psoriasis duration, earlier year of biologic initiation, prior nonbiologic systemic therapy use, history of hyperlipidemia, and Medicaid insurance were significantly associated with MBF, though the latter 2 variables exhibited wider confidence intervals, indicating a lower level of support. The first-to-second biologic sequence most observed with MBF was Tumor necrosis factor-α inhibitor to IL-17 inhibitor use.Biologic adherence between visits was not evaluated.Approximately 6% of psoriasis patients met MBF criteria. The results identify characteristics associated with MBF that may distinguish patients warranting more frequent follow-up.
科研通智能强力驱动
Strongly Powered by AbleSci AI