化学
环氧乙烷
表面改性
组合化学
酒
纳米技术
有机化学
物理化学
材料科学
作者
Subir Paul,Dario Filippini,Filippo Ficarra,Heorhii Melnychenko,Christopher Janot,Mattia Silvi
摘要
Oxetanes are strained heterocycles with unique properties that have triggered significant advances in medicinal chemistry. However, their synthesis still presents significant challenges that limit the use of this class of compounds in practical applications. In this Letter, we present a methodology that introduces a new synthetic disconnection to access oxetanes from native alcohol substrates. The generality of the approach is demonstrated by the application in late-stage functionalization chemistry, which is further exploited to develop a single-step synthesis of a known bioactive synthetic steroid derivative that previously required at least four synthetic steps from available precursors.
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