河马信号通路
生物
串扰
信号转导
雅普1
细胞生物学
PDZ域
癌症研究
效应器
转录因子
遗传学
基因
光学
物理
作者
Beatrice Messina,Federica Lo Sardo,Stefano Scalera,Lorenzo Memeo,Cristina Colarossi,Marzia Mare,Giovanni Blandino,Gennaro Ciliberto,Marcello Maugeri‐Saccà,Giulia Bon
标识
DOI:10.1038/s41419-023-05568-8
摘要
The Hippo pathway plays a critical role for balancing proliferation and differentiation, thus regulating tissue homeostasis. The pathway acts through a kinase cascade whose final effectors are the Yes-associated protein (YAP) and its paralog transcriptional co‑activator with PDZ‑binding motif (TAZ). In response to a variety of upstream signals, YAP and TAZ activate a transcriptional program that modulates cellular proliferation, tissue repair after injury, stem cell fate decision, and cytoskeletal reorganization. Hippo pathway signaling is often dysregulated in gastric cancer and in Helicobacter pylori-induced infection, suggesting a putative role of its deregulation since the early stages of the disease. In this review, we summarize the architecture and regulation of the Hippo pathway and discuss how its dysregulation fuels the onset and progression of gastric cancer. In this setting, we also focus on the crosstalk between Hippo and other established oncogenic signaling pathways. Lastly, we provide insights into the therapeutic approaches targeting aberrant YAP/TAZ activation and discuss the related clinical perspectives and challenges.
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