Enhancing polyphenol extraction efficiency: A systematic review on the optimization strategies with natural deep eutectic solvents

Polyphenols, derived from plants, are biologically active components with broad applications across multiple industrial sectors. Extracting them from raw materials is crucial in their potential utilization, underscoring the importance of selecting effective solvents and extraction techniques. This systematic review explores the viability of employing natural deep eutectic solvents (NADES) for polyphenol extraction. The emphasis was placed on enhancing the polyphenol extraction process using the response surface methodology (RSM) in studies conducted within the last six years involving solvent extraction and microwave and ultrasound assistance. Various extraction methods and NADES solvents are examined for their polyphenol recovery potential, with effectiveness comparisons and identification of commonly used analytical techniques. The review also highlights potential pathways for optimization, enabling a sustainable strategy for recovering valuable raw materials from various sources through modern, environmentally friendly solutions.