Background: To enhance the longevity of adhesive restorations, dentin collagen collapse prevention and preservation of matrix molecules are crucial to arrest the matrix metalloproteinase activation. Aim: The aim of this study was to assess the polymeric chelating conditioners' impact on the microtensile adhesive strength as well as resin-dentin interfacial durability. Materials and Methods: ≤ 0.05). Results: = 0.938). Conclusion: Dentin conditioning with polymeric chelating agents has significantly improved the immediate and after aging adhesive strength of resin-dentin interface.