伊萨丁
化学
催化作用
曼尼希反应
产量(工程)
亲核细胞
奥西多尔
恶唑啉
组合化学
对映选择合成
有机化学
药物化学
材料科学
冶金
作者
Yao‐Bin Shen,Hui-Ling Qian,Lei Yang,Shun Zhou,Han-Wen Rao,Zhen-Hua Wang,Yong You,Yanping Zhang,Jun-Qing Yin,Jian‐Qiang Zhao,Wenjing Zhang,Wei‐Cheng Yuan
出处
期刊:Organic Letters
[American Chemical Society]
日期:2024-02-22
卷期号:26 (8): 1699-1704
标识
DOI:10.1021/acs.orglett.4c00227
摘要
The first direct catalytic asymmetric Mannich reaction of 2-alkylazaarenes and ketimines was realized with a chiral Cu-bis(oxazoline) complex as the catalyst. The asymmetric addition of 2-alkylpyridines to isatin-derived ketimines proceeded smoothly to afford α,β-functionalized 2-substituted pyridines bearing 3-amino-3,3-disubstituted oxindole motifs with excellent results (≤99% yield, 99:1 dr, and 98% ee). The catalytic system was also extended to 2-alkylbenzothiazoles as nucleophiles for the asymmetric Mannich reaction of ketimines.
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