Effect of Multidrug Resistance Gene and AGTR1 (1166A>C) Gene Polymorphism on Hypertension and Its Relationship with Antihypertensive Effect of Valsartan

To analyze the relationship between the gene polymorphism of multidrug resistance gene and AGTR1 (1166A>C) gene and the susceptibility factors of hypertension in Northeast China, and to analyze the effect of valsartan on the antihypertensive effect from the perspective of pharmacodynamics. This study included 2250 healthy controls and 2250 patients with hypertension in Jiamusi area. Genotypes were detected by fluorescence staining in situ hybridization. The blood drug concentration was determined by high performance liquid chromatography. In this study, the allele frequency, blood concentration and antihypertensive effect of valsartan were analyzed. The distribution frequency of AGTR1 A1166C genotype was: 2250 cases in the case group, including 88.13% of AA type, 11.47% of AC type and 0.4% of CC type. 2250 cases in the control group, including 90.04% of AA type, 9.96% of AC type and 0 cases of CC type. The distribution frequency of ABCB1 C3435T genotype was 2250 cases in the case group, of which the frequency of CC type was 39.24%, CT type was 45.64%, TT type was 15.11%, and 2250 cases in the control group, of which the frequency of CC type was 39.11%, CT type was 43.33%, TT type was 17.56%. By monitoring the blood drug concentration and blood pressure decrease of patients taking valsartan, it was found that the blood drug concentration of AA genotype in AGTR1 A1166C genotype was high, the blood pressure decreased greatly, and the antihypertensive effect was good; In ABCB1 C3435T genotype, TT genotype has high blood drug concentration, large decrease in blood pressure and good antihypertensive effect. By comparing the genotype frequencies of healthy control group and case group, it is concluded that the gene polymorphisms of AGTR1 and ABCB1 are not susceptible factors of hypertension and have no significant relationship with the prevalence of hypertension, but have an impact on the efficacy of antihypertensive drug valsartan. The antihypertensive effects of different genotypes are different. Patients with A allele and T allele have better antihypertensive effects after taking valsartan.