Promises and challenges of organoids: From humanized to human derived

Kastenschmidt et al. 1 Kastenschmidt J.M. Schroers-Martin J.G. Sworder B.J. Sureshchandra S. Khodadoust M.S. Liu C.L. Olsen M. Kurtz D.M. Diehn M. Wagar L.E. et al. A human lymphoma organoid model for evaluating and targeting the follicular lymphoma tumor immune microenvironment. Cell Stem Cell. 2024; 31: 410-420.e4 Abstract Full Text Full Text PDF Scopus (1) Google Scholar present a groundbreaking organoid culture model for follicular lymphoma, which is capable of maintaining stable compositions of B and T cells. This model is utilized in testing bispecific antibodies in effective killing of tumor B cells with the activation of T cells. Kastenschmidt et al. 1 Kastenschmidt J.M. Schroers-Martin J.G. Sworder B.J. Sureshchandra S. Khodadoust M.S. Liu C.L. Olsen M. Kurtz D.M. Diehn M. Wagar L.E. et al. A human lymphoma organoid model for evaluating and targeting the follicular lymphoma tumor immune microenvironment. Cell Stem Cell. 2024; 31: 410-420.e4 Abstract Full Text Full Text PDF Scopus (1) Google Scholar present a groundbreaking organoid culture model for follicular lymphoma, which is capable of maintaining stable compositions of B and T cells. This model is utilized in testing bispecific antibodies in effective killing of tumor B cells with the activation of T cells. A human lymphoma organoid model for evaluating and targeting the follicular lymphoma tumor immune microenvironmentKastenschmidt et al.Cell Stem CellFebruary 22, 2024In BriefUsing primary follicular lymphoma tumor biopsies, Kastenschmidt et al. develop a patient-derived lymphoma organoid model demonstrating in vitro microenvironment stability over 3 weeks without exogenous cytokines. Treated with bispecific immunotherapies, organoids recapitulated T cell-mediated lymphoma killing, allowing investigation of patient-specific microenvironment determinants of response. Full-Text PDF Open Access