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Ultrasound-Assisted, Catheter-Directed Thrombolysis for Acute Intermediate/High-Risk Pulmonary Embolism: Design of the Multicenter USAT IH-PE Registry and Preliminary Results

医学 溶栓 肺栓塞 内科学 临床终点 心脏病学 入射(几何) 肺动脉高压 血运重建 外科 心肌梗塞 临床试验 物理 光学
作者
Claudia Colombo,Nicolò Capsoni,Filippo Russo,Mario Iannaccone,Marianna Adamo,Giovanna Viola,Ilaria Bossi,Luca Villanova,Chiara Tognola,Camilla Curci,Francesco Morelli,Rossella Guerrieri,Lucia Occhi,Giuliano Chizzola,Antonio Rampoldi,Francesco Musca,Giuseppe De Nittis,Mario Galli,Giacomo Boccuzzi,Daniele Savio
出处
期刊:Journal of Clinical Medicine [Multidisciplinary Digital Publishing Institute]
卷期号:13 (2): 619-619 被引量:3
标识
DOI:10.3390/jcm13020619
摘要

Catheter-based revascularization procedures were developed as an alternative to systemic thrombolysis for patients with intermediate-high- and high-risk pulmonary embolisms. USAT IH-PE is a retrospective and prospective multicenter registry of such patients treated with ultrasound-facilitated, catheter-directed thrombolysis, whose preliminary results are presented in this study. The primary endpoint was the incidence of pulmonary hypertension (PH) at follow-up. Secondary endpoints were short- and mid-term changes in the echocardiographic parameters of right ventricle (RV) function, in-hospital and all-cause mortality, and procedure-related bleeding events. Between March 2018 and July 2023, 102 patients were included. The majority were at intermediate–high-risk PE (86%), were mostly female (57%), and had a mean age of 63.7 ± 14.5 years, and 28.4% had active cancer. Echocardiographic follow-up was available for 70 patients, and in only one, the diagnosis of PH was confirmed by right heart catheterization, resulting in an incidence of 1.43% (CI 95%, 0.036–7.7). RV echocardiographic parameters improved both at 24 h and at follow-up. In-hospital mortality was 3.9% (CI 95%, 1.08–9.74), while all-cause mortality was 11% (CI 95%, 5.4–19.2). Only 12% had bleeding complications, of whom 4.9% were BARC ≥ 3. Preliminary results from the USAT IH-PE registry showed a low incidence of PH, improvement in RV function, and a safe profile.
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