细菌
金黄色葡萄球菌
双金属片
抗生素
膜透性
抗菌剂
化学
微生物学
骨髓炎
活性氧
材料科学
膜
微波食品加热
催化作用
医学
生物
外科
生物化学
量子力学
物理
遗传学
作者
Wenchan Sun,Chaofeng Wang,Danya Wan,Yufeng Zheng,Shuilin Wu,Jie Shen,Yu Zhang,Xiangmei Liu
标识
DOI:10.1002/smtd.202300203
摘要
Abstract Osteomyelitis caused by bacteria is a deep‐seated lesion and is often treated clinically with antibiotics. Long‐term use of antibiotics may predispose bacteria to develop resistance. Here, CuCeO x material is applied to treat infectious bacterial osteomyelitis using microwave (MW)‐assisted bacterial killing. Heat generation occurs as a result of the dielectric properties of the material under MW irradiation, and the material generates reactive oxygen species (ROS) under MW irradiation. Heat and ROS increase the thermal sensitivity and permeability of bacterial cell membranes, and the released copper ions easily penetrate the bacterial membrane and react with H 2 O 2 to produce a toxic hydroxyl group inside the bacteria, leading to the bacteria's eventual death. This is due to the synergistic effect of the MW thermal effect, ROS, and the breaking of the equilibrium within the bacteria. CuCeO x can effectively treat osteomyelitis caused by Staphylococcus aureus using MW irradiation. This study can safely and effectively address the challenge of deep tissue infections by shedding light on non‐invasive antimicrobial systems and using MW thermal therapy and MW dynamics to achieve therapeutic results.
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