酒精使用障碍
大麻酚
背景(考古学)
睡眠障碍
医学
精神科
失眠症
大麻
酒
古生物学
生物化学
化学
生物
作者
Marie Gendy,Benício N. Frey,Michael Van Ameringen,Nirushi Kuhathasan,James MacKillop
出处
期刊:Alcohol and Alcoholism
[Oxford University Press]
日期:2023-05-03
卷期号:58 (4): 337-345
标识
DOI:10.1093/alcalc/agad031
摘要
Abstract Among individuals with alcohol use disorder (AUD), it is estimated that the majority suffer from persistent sleep disturbances for which few candidate medications are available. Our aim wass to critically review the potential for cannabidiol (CBD) as a treatment for AUD-induced sleep disturbance. As context, notable side effects and abuse liability for existing medications for AUD-induced sleep disturbance reduce their clinical utility. CBD modulation of the endocannabinoid system and favorable safety profile have generated substantial interest in its potential therapeutic use for various medical conditions. A number of preclinical and clinical studies suggest promise for CBD in restoring the normal sleep–wake cycle and in enhancing sleep quality in patients diagnosed with AUD. Based on its pharmacology and the existing literature, albeit primarily preclinical and indirect, CBD is a credible candidate to address alcohol-induced sleep disturbance. Well-designed RCTs will be necessary to test its potential in managing this challenging feature of AUD.
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