姜黄素
生物利用度
黑质
MPTP公司
帕金森病
多巴胺能
药理学
医学
体内
多巴胺
疾病
内科学
生物
生物技术
作者
Xiwen Geng,Hao Zhang,Minghui Hu,Xiaoyu Liu,Min‐Koo Han,Jinlu Xie,Zifa Li,Feng Zhang,Wei Liu,Sheng Wei
标识
DOI:10.3389/fnagi.2022.984895
摘要
Curcumin has been reported to improve or prevent movement disorders in Parkinson's disease (PD); however, its low bioavailability is the biggest obstacle to its application. To optimize the limited efficacy of curcumin and to improve its protective effects against PD, we prepared and tested a novel curcumin oil solution. In vivo imaging was used to confirm that the curcumin oil solution has higher bioavailability than curcumin alone. To test its motor effects on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced movement disorders, behavioral tests, including the open-field test, pole test, rotarod test, and automated gait analysis were used. Finally, pathological evaluation using immunohistochemistry and western blotting analysis was done. Encouragingly, the behavioral test findings exhibited a better protective effect against MPTP-induced movement disorders. In addition, it had a greater protective effect on dopaminergic neurons in the compact part of the substantia nigra along with the PD process according to pathological evaluation. This novel curcumin oil solution may provide a new choice for PD prevention as a dietary supplement or clinically assisted treatment based on its better bioavailability and efficiency.
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