Click Reactivity of Azide-Modified Polyvinyl Chloride as an Entry to Glycopolymer Scaffolds

We report the synthesis of new carbohydrate/triazole polymers based on poly(viny chloride) (PVC).Azide incorporation into commercially available PVC was carried out using nucleophilic substitution and Cu-catalyzed reaction of the resulting PVC-N3 using three alkynylcontaining acetonide-protected monosaccharides (based on D-glucose and D-galactose) provided a set of PVC-based polymers incorporating a triazolyl linkage with monosaccharide moieties present on the periphery.Modified polymers were characterized by using Fourier transform infrared (FT-IR), Nuclear Magnetic Resonance ( 1 H-NMR and 13 C-NMR) spectroscopy, together with thermogravimetric and surface morphological analysis.