青藤碱
细胞培养
化学
立体化学
A549电池
癌症研究
组合化学
细胞
药理学
生物化学
医学
生物
遗传学
作者
Can-Jing Wei,Fang Xu,Mengjiao Shi,Jiawen Hu,Jiajia Wang,Bo Zhen,Xue Wang,Tengfei Ji,Jinhua Wang,Guanhua Du
标识
DOI:10.1080/10286020.2017.1386659
摘要
A series of new sinomenine derivatives were designed, synthesized, and evaluated in tumor inhibitory activity, such as human triple negative breast cancer cell line (MDA-MB-231), glioma cell line (A172), human lung cancer cell line (A549), human colon cancer cell line (HCT-8). The modifications were carried out on rings A and C of the sinomenine by esterificating on phenolic hydroxyl with good yields. The highlight of this work was that the synthetic procedures were concise and sinomenine derivatives demonstrated promising antitumor activities.
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