先天性淋巴细胞
免疫系统
上睑下垂
获得性免疫系统
作者
Lorenzo Galluzzi,Claire Vanpouille-Box
标识
DOI:10.1016/j.tcb.2018.02.010
摘要
Large BAX/BAK pores that form during apoptosis enable mitochondrial nucleoids to access the cytosol, potentially leading to inflammatory signaling via CGAS. Under physiological conditions, however, BAX/BAK-dependent caspase activation rapidly dismantles dying cells to prevent inflammatory responses. BAX and BAK operate at the interface between apoptotic signaling and innate immunity control.
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