伊克泽珠单抗
塞库金单抗
银屑病
白细胞介素17
斑块性银屑病
医学
促炎细胞因子
免疫学
趋化因子
单克隆抗体
白细胞介素
白细胞介素23
免疫系统
细胞因子
抗体
炎症
银屑病性关节炎
作者
Melinda Gooderham,Posso-De Los Rios Cj,Rubio-Gomez Ga,Kim Papp
出处
期刊:PubMed
日期:2015-03-26
卷期号:20 (1): 1-5
被引量:12
摘要
Acting on keratinocytes to produce antimicrobial peptides and chemokines, which in turn attract neutrophils and other inflammatory cells, interleukin-17 (IL-17) is believed to be a potent driver of plaque psoriasis. Its proinflammatory characteristics make IL-17 an attractive therapeutic target for addressing immune dysregulation. This review examines the role of IL-17 in the pathogenesis of plaque psoriasis and the potential implications of its inhibition. The efficacy and safety results from Phase 2 and 3 trials with monoclonal antibodies targeting IL-17RA (brodalumab), and IL-17A (ixekizumab and secukinumab) validate IL-17 as an effective therapeutic target for the treatment of plaque psoriasis.
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