体内
克拉霉素
自愈水凝胶
PEG比率
聚乙二醇
医学
药物输送
抗生素
材料科学
药理学
化学
纳米技术
生物
生物化学
生物技术
经济
高分子化学
财务
作者
Zhengming Chen,Zhengwei Cai,Chengjing Zhu,Xianmin Song,Yanghua Qin,Minhui Zhu,Tao Zhang,Wenguo Cui,Haihong Tang,Hongliang Zheng
标识
DOI:10.1002/adhm.202001032
摘要
Abstract Systemic antibiotic therapy is the main treatment for acute bacterial rhinosinusitis (ABRS). However, this treatment often causes side effects of dizziness, diarrhea, and drug resistance. In this study, a new polyethylene glycol hydrogel (PEG‐H) treatment model is developed to achieve sustained release of drugs at the locality while avoiding those adverse effects. The PEG‐H is composed of 4‐arm‐PEG‐SH and silver ions through a high affinity and dynamic reversible coordination bond between the thiol and silver ion. In the initial test, PEG‐H is loaded with Clarithromycin (CAM‐Lips@Hydrogel) or Clarithromycin and Budesonide liposomes (CAM+BUD‐Lips@Hydrogel). The results show that PEG‐H maintains the characteristics of self‐healing, biodegradability, moderate swelling rate, injectibility and sustained drug release. In in vivo studies, the hydrogel is injected into the maxillary sinus of ABRS rabbit models. In both a single or combined load, the hydrogel not only plays an effective role as an anti‐bacterial, but also inhibits inflammatory response of local sinus mucosa. In addition, no other side effects are observed in the ABRS rabbit model through behavioral observation and drug sensitivity tests. Therefore, the injectable self‐healing hydrogel with anti‐bacterial and anti‐inflammatory properties provides a new micro invasive therapeutic method for the clinical treatment of ABRS.
科研通智能强力驱动
Strongly Powered by AbleSci AI