免疫原性细胞死亡
程序性细胞死亡
免疫系统
细胞凋亡
癌症研究
细胞
纤维肉瘤
体外
凋亡细胞死亡
医学
免疫学
免疫疗法
生物
病理
生物化学
遗传学
作者
Daolin Tang,Oliver Kepp,Guido Kroemer
出处
期刊:OncoImmunology
[Landes Bioscience]
日期:2020-12-29
卷期号:10 (1): 1862949-1862949
被引量:96
标识
DOI:10.1080/2162402x.2020.1862949
摘要
Ferroptosis is an iron-dependent form of non-apoptotic cell death that has recently been attributed with antitumor immune effects. Thus, early ferroptotic cells underwent immunogenic cell death that was accompanied by the emission of damage-associated molecular patterns (DAMPs) and triggered dendritic cell maturation in vitro. Furthermore, ferroptotic cells were able to vaccinate against a rechallenge with fibrosarcoma in preclinical models.
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