Human placenta‐derived mesenchymal stem cells induce trophoblast invasion via dynamic effects on mitochondrial function

Abstract The trophoblast is a critical cell for placental development and embryo implantation in the placenta. We previously reported that placenta‐derived mesenchymal stem cells (PD‐MSCs) increase trophoblast invasion through several signaling pathways. However, the paracrine effects of PD‐MSCs on mitochondrial function in trophoblasts are still unclear. Therefore, the objective of the study was to analyze the mitochondrial function of trophoblasts in response to cocultivation with PD‐MSCs. The results showed that PD‐MSCs regulate the balance between cell survival and death and protect damaged mitochondria in trophoblasts from oxidative stress. Moreover, PD‐MSCs upregulate factors involved in mitochondrial autophagy in trophoblast cells. Finally, PD‐MSCs improve trophoblast invasion. Taken together, the data indicate that PD‐MSCs can regulate trophoblast invasion through dynamic effects on mitochondrial energy metabolism. These results support the fundamental role of mitochondrial energy mechanism in trophoblast invasion and suggest a new therapeutic strategy for infertility.