Mechanisms of adrenal insufficiency in sepsis

Adrenal insufficiency is a common complication in sepsis patients, with a higher morbidity in septic shock patients.Adrenal insufficiency is closely related to coagulation disorders, inflammatory mediators and glucocorticoid resistance.The mechanisms of adrenal insufficiency in sepsis have not been discussed clearly.In the present review we detail the mechanisms of adrenal insufficiency that are active during sepsis. Key words: Sepsis; Adrenal insufficiency; Mechanism; Steroid