动态功能连接
相关性
连接体
默认模式网络
人口
功能连接
作者
Anita D. Barber,Catherine E. Hegarty,Martin A. Lindquist,Katherine H. Karlsgodt
出处
期刊:Cerebral Cortex
[Oxford University Press]
日期:2021-05-10
卷期号:31 (6): 2834-2844
被引量:4
标识
DOI:10.1093/cercor/bhaa391
摘要
Recent efforts to evaluate the heritability of the brain's functional connectome have predominantly focused on static connectivity. However, evaluating connectivity changes across time can provide valuable insight about the inherent dynamic nature of brain function. Here, the heritability of Human Connectome Project resting-state fMRI data was examined to determine whether there is a genetic basis for dynamic fluctuations in functional connectivity. The dynamic connectivity variance, in addition to the dynamic mean and standard static connectivity, was evaluated. Heritability was estimated using Accelerated Permutation Inference for the ACE (APACE), which models the additive genetic (h2), common environmental (c2), and unique environmental (e2) variance. Heritability was moderate (mean h2: dynamic mean = 0.35, dynamic variance = 0.45, and static = 0.37) and tended to be greater for dynamic variance compared to either dynamic mean or static connectivity. Further, heritability of dynamic variance was reliable across both sessions for several network connections, particularly between higher-order cognitive and visual networks. For both dynamic mean and static connectivity, similar patterns of heritability were found across networks. The findings support the notion that dynamic connectivity is genetically influenced. The flexibility of network connections, not just their strength, is a heritable endophenotype that may predispose trait behavior.
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