光动力疗法
甲基丙烯酸缩水甘油酯
转染
遗传增强
细胞毒性
材料科学
光敏剂
癌症研究
纳米技术
生物物理学
化学
生物化学
生物
体外
基因
有机化学
复合材料
聚合物
聚合
作者
Chen Xu,Wenting Hu,Na Zhang,Yu Qi,Jing‐Jun Nie,Nana Zhao,Bingran Yu,Fu‐Jian Xu
出处
期刊:Biomaterials
[Elsevier]
日期:2020-07-01
卷期号:248: 120031-120031
被引量:32
标识
DOI:10.1016/j.biomaterials.2020.120031
摘要
Multimodal therapy has been continuously explored for different diseases. Photodynamic/gene combined therapy is a promising treatment strategy of tumor. However, the limitation of traditional chemical photosensitizer and the asynchronism of the two therapies restrict the development of this technology. Herein, one genetically multimodal treatment nanosystem ([email protected]/pKR-p53), composed of biocompatible hydroxyethyl starch (HES), low-toxic β-cyclodextrin-based ethanolamine-functionalized poly(glycidyl methacrylate) (CD-PGEA) and combined plasmid pKR-p53, is structurally designed based on host-guest assembly and electrostatic complexing. Supramolecular assembled [email protected] exhibits low cytotoxicity, excellent cellular internalization and enhanced gene transfection efficiency. With the delivery of pKR-p53, p53 and KillerRed proteins could be expressed simultaneously in the same tumor cell for p53-mediated apoptosis therapy and photodynamic therapy (PDT), where the synergistic effect of KillerRed and p53 proteins is achieved. Compared with single therapy, [email protected]/pKR-p53 shows more remarkable antitumor effects in the 4T1 tumor model.
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