Super-enhancer-driven SGK1 activates polyamine metabolism to promote autoimmune uveitis.

) balance, whereas polyamine supplementation negates these therapeutic benefits, confirming SGK1's role in driving disease progression. Notably, through molecular docking and molecular dynamics simulations, we identified herbacetin as a natural inhibitor of SGK1. Herbacetin restores immune balance and mitigates disease severity, highlighting SGK1 as a promising therapeutic target for autoimmune uveitis.