Bacteria-Derived Nanobody-Decorated Nanoplatform Restores T Cell Immunity Post-Radiotherapy

T cell infiltration, reduces exhausted T cell populations, maintains cytotoxic T lymphocyte function, and inhibits tumor progression and metastasis. Our study elucidates a dual mechanism underlying radiotherapy-induced immunosuppression and offers a promising strategy to enhance radioimmunotherapy outcomes through targeted metabolic and immunologic reprogramming.