螨
医学
免疫球蛋白E
过敏
免疫学
屋尘螨
敏化
过敏性
过敏原
草甘膦科
哮喘
嗜酪蛋白
生物
抗体
植物
作者
Raquel López-Rodríguez,Manuel Jorge Rial,Ignacio Esteban-Gorgojo,Beatriz Veleiro Pérez,Gustavo Adolfo López-Araújo,Olinda Pérez-Quintero,Clara Carballás,Antonio Parra,Fernando Pineda
出处
期刊:International Archives of Allergy and Immunology
[S. Karger AG]
日期:2022-01-01
卷期号:183 (8): 843-851
被引量:6
摘要
<b><i>Background/Objective:</i></b> The objective of this study was to describe the molecular sensitization profile of mite allergy in an area with a high environmental exposure of house dust mites (HDM) and storage mites. <b><i>Methods:</i></b> Skin prick tests were performed with standardized extracts (DIATER, Madrid, Spain). A specific commercial molecular panel (MADx) for <i>Dermatophagoides pteronyssinus</i> (Dpt), <i>Dermatophagoides farinae</i> (Dfar), <i>Lepidoglyphus destructor</i> (Ldt), <i>Tyrophagus putrescentiae</i> (Tput), and <i>Blomia tropicalis</i> (Blot) was correlated with clinical parameters in Galician (northwestern of Spain) HDM allergic patients. <b><i>Results:</i></b> Fifty patients (60% female) met the inclusion and exclusion criteria. All of the patient’s present rhinitis (50), 28% (14) rhinitis and asthma, and 18% (9) atopic dermatitis (AD). Hundred patients had a positive prick test for Dpt, followed by Dfar (92%), Ldt and Tput (74%), and Blot (68%). More than 50% recognized specific IgE for Der p 1, Der p 2, reaching 86% in the case of Der p 23. No statistically significant differences in IgE levels were found between patients with/without asthma and those with mild or moderate-severe rhinitis. Der p 7 was higher among rhinitis patients (<i>p</i> value 0.05). AD relative risk (RR) was increased in patients sensitized to Der f 2, Der p 2, and Der p 23. Der p 10 decreases the risk to have AD (RR 0.80). <b><i>Conclusion:</i></b> The evaluation of IgE results in a comprehensive panel of allergens allows differentiation of serological reactivity profiles with their clinical expression, to perform an optimal management. Improvements in component resolved diagnosis and more research on the clinical relevance of mite allergens are needed to achieve a genuine diagnosis leading to specific immunotherapy.
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